Colonic Mucosal Interleukin-6 in Inflammatory Bowel Disease
作者:
Keiichi Mitsuyama,
Ei Sasaki,
Atsushi Toyonaga,
Hideo Ikeda,
Osamu Tsuruta,
Akira Irie,
Nobuyuki Arima,
Tetsuharu Oriishi,
Kazunori Harada,
Kazuhiro Fujisaki,
Michio Sata,
Kyuichi Tanikawa,
期刊:
Digestion
(Karger Available online 1991)
卷期:
Volume 50,
issue 2
页码: 104-111
ISSN:0012-2823
年代: 1991
DOI:10.1159/000200747
出版商: S. Karger AG
关键词: Ulcerative colitis;Crohn’s disease;Interleukin-6
数据来源: Karger
摘要:
Interleukin-6, a cytokine produced by various cell types, has a major role in inflammatory and immunological reactions. To define its potential role in inflammatory bowel disease, its concentrations in endoscopic biopsy samples from patients with ulcerative colitis and Crohn’s disease were measured. The involved colonic mucosa from active disease was found to contain significantly larger amounts of interleukin-6 than that from inactive disease or normal controls. Colonic mucosal interleukin-6 levels correlated well with the grade of macroscopic inflammation, especially in patients with ulcerative colitis. The levels of interleukin-6 decreased in parallel with clinical improvement following the start of therapy in patients with both forms of inflammatory bowel disease. Mucosal interleukin-6 is thus concluded to accurately reflect the degree of colonic inflammation and may be importantly associated with inflammatory and immunological phenomena seen in inflammatory bowel diseas
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