Human β‐nerve growth factor does not crossreact with antibodies to mouse β‐nerve growth factor in a two‐site radioimmunoassay
作者:
Carol E. Beck,
J. Regino Perez‐Polo,
期刊:
Journal of Neuroscience Research
(WILEY Available online 1982)
卷期:
Volume 8,
issue 2‐3
页码: 137-152
ISSN:0360-4012
年代: 1982
DOI:10.1002/jnr.490080205
出版商: Wiley Subscription Services, Inc., A Wiley Company
关键词: nerve growth factor;NGF;human NGF;radioimmunoassay
数据来源: WILEY
摘要:
AbstractThe nerve growth factor protein (NGF) isolated from mouse submaxillary gland has been shown to be necessary to the development of vertebrate sensory and sympathetic ganglia. Also, wide ranging alterations in the levels of NGF in the peripheral circulation of humans suffering from a variety of neuropathies have been reported. Many of these reports relied on the use of antibodies directed to the mouse β‐NGF subunit for their quantitation of human NGF antigen. We report here on the lack of crossreaction between antibodies directed to mouse β‐NGF and its human counterpart isolated from placenta at
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