Induction of Helper t Cells by Pertussis Toxin During in Vlvo Priming to Insulin
作者:
GrenierN.,
BettetiniD.,
FehlmannM.,
L.J,
期刊:
Immunopharmacology and Immunotoxicology
(Taylor Available online 1991)
卷期:
Volume 13,
issue 1-2
页码: 73-86
ISSN:0892-3973
年代: 1991
DOI:10.3109/08923979109019692
出版商: Taylor&Francis
数据来源: Taylor
摘要:
AbstractWe have studied the effect of pertussis toxin (PT) onin vivopriming of T lymphocytes to insulin. Mice were immunized with bovine insulin in complete Freund's adjuvant and antigen-specific DNA synthesis was measured in lymphoid cell suspensions from lymph nodes and spleens. Insulin-specific response was greatly enhanced both in spleen and lymph nodes if mice were given PT at the time of immunization. Mice given PT presented 3 times more cells in spleen and 4 times less in lymph nodes. However, the major antigen-specific response was still observed in lymph nodes. PT had a strong mitogenic effectin vitroon lymph node cells but a weak effect on spleen cells indicating that the adjuvant activity of PT involves other effects besides the mitogenic activity.
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