Ketoconazole‐induced hepatitis: a case with a definite cause‐effect relationship
作者:
G. Parys,
C. Evenepoel,
B. Damme,
V. J. Desmet,
期刊:
Liver
(WILEY Available online 1987)
卷期:
Volume 7,
issue 1
页码: 27-30
ISSN:0106-9543
年代: 1987
DOI:10.1111/j.1600-0676.1987.tb00311.x
出版商: Blackwell Publishing Ltd
关键词: drug;hepatitis;ketoconazole
数据来源: WILEY
摘要:
ABSTRACT—We present the case of a female patient in whom acute hepatitis developed after 180 days of ketoconazole administration (200 mg/day). A prompt renewed hepatic injury after an unintentional rechallenge 6 months later provided definitive evidence for a causative relationship between ketoconazole and acute liver disease. The clinical and biochemical parameters of the case are reported. Histological examination revealed the picture of acute hepatitis with possible transition to chronicity. A prominent accumulation of perisinusoidal lipocytes (Ito cells) was observe
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