Combined Therapy with Vasodilator Drugs and Beta‐Adrenergic Blockade in HypertensionA Comparative Study of Minoxidil and Hydralazine
作者:
Thomas Gottlieb,
Fred Katz,
Charles Chidsey,
期刊:
Circulation
(OVID Available online 1972)
卷期:
Volume 45,
issue 3
页码: 571-582
ISSN:0009-7322
年代: 1972
出版商: OVID
关键词: Antihypertensive therapy;Propranolol;Renin;Aldosterone
数据来源: OVID
摘要:
The hypotensive efficacies of two vasodilators, hydralazine and minoxidil, were assessed as these drugs were used individually in combination with beta-adrenergic blockade and diuretics in 11 hypertensive patients in whom elevated blood pressure had not been adequately controlled previously by other antihypertensive therapy.Control supine blood pressure fell from 191/128 mm Hg on propranolol and hydrochlorothiazide to 169/108 mm Hg on hydralazine, with a significantly greater reduction to 142/92 mm Hg on minoxidil. Although sodium retention and tachycardia were controlled by the use of concomitant diuretics and beta-blockade, an increment in each of these drugs was occasionally required to prevent these complications. Renal function was changed little with the decrease in blood pressure. Plasma renin increased from a standing control of 14.5 mμg/ml/hr to 35.9 and 31.1 mμg/ml/hr, respectively, on hydralazine and minoxidil. These data suggest the role of vasodilators used in combination with beta-blockers and diuretics and indicate the greater therapeutic efficacy of minoxidil.
点击下载:
PDF
(1591KB)
返 回