Craniometric measurements of craniofacial malformations in the X‐linked hypophosphatemic (Hyp) mouse on two different genetic backgrounds: C57BL/6J and B6C3H
作者:
Cesar D. Gonzalez,
Ralph A. Meyer,
Robert J. Iorio,
期刊:
Teratology
(WILEY Available online 1992)
卷期:
Volume 46,
issue 6
页码: 605-613
ISSN:0040-3709
年代: 1992
DOI:10.1002/tera.1420460610
出版商: Wiley Subscription Services, Inc., A Wiley Company
数据来源: WILEY
摘要:
AbstractThis study reports data on craniometric measurements in the X‐linked hypophosphatemic (Hyp) mouse on two different genetic backgrounds: C57BL/6J and B6C3H. Heads of normal females “+/+,” normal males “+/Y,” heterozygous mutant females “Hyp/+,” and hemizygous mutant males “Hyp/Y” for each genetic background were examined. Data were collected via skull measurements.On a C57BL/6J background, the neurocranium of mutants “Hyp/+” and “Hyp/Y” was shorter and slightly higher than in normal counterparts.On a B6C3H background, mutant mice “Hyp/+” and “Hyp/Y” were shorter in neurocranial length than in normal counterparts. Viscerocranial height was larger in “Hyp/Y” than in normal counterparts. No differences in neurocranial and mandibular height were found.Mutant mice on a C57BL/6J background were compared to mutant mice on a B6C3H background.No differences in neurocranial length were found. Cranial length was shorter in “Hyp/Y” on C57BL/6J than in “Hyp/+” on B6C3H. Facial length parameters were shorter in “Hyp/Y” on C57BL/6J than in “Hyp/Y” and “Hyp/+” mutant mice on B6C3H. Mandibular length was shorter in “Hyp/Y” on C57BL/6J than in “Hyp/+” on C57BL/6J and both mutant mice (“Hyp/Y” and “Hyp/+”) on a B6C3H background. The results of this study indicate that craniofacial growth is less affected in mutant mice on a B6C3H genetic background tha
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