Uremic Pruritus and Skin Mast Cells
作者:
Nada Dimković,
Ljubica Djukanović,
Aleksandar Radmilović,
Petar Bojić,
Todor Juloski,
期刊:
Nephron
(Karger Available online 1992)
卷期:
Volume 61,
issue 1
页码: 5-9
ISSN:1660-8151
年代: 1992
DOI:10.1159/000186826
出版商: S. Karger AG
关键词: Uremic pruritus;Skin mast cells;Histamine;Middle molecular weight substances
数据来源: Karger
摘要:
The number of mast cells in the skin was evaluated in 25 patients with end-stage renal failure on different treatment modality (conservative, hemodialysis and peritoneal dialysis). According to the presence of pruritus, uremic patients were divided into two groups: group A, 13 patients with diffuse pruritus, and group B, 12 patients without pruritus. Controls were 6 age- and sex-matched healthy subjects. In comparison with patients without pruritus, patients with pruritus had mainly degranulated, diffusely spread and more numerous mast cells in the skin; significantly higher levels of plasma middle molecular weight substances, serum histamine and PTH and significantly lower serum iron levels. However, no differences were noted in observed parameters between groups on different treatment modalities. Favorable therapeutic effects in patients with pruritus were achieved either with iron supplementation in those with hypoferremia or with antihistamines, mast cell membrane stabilizers and high-permeability membranes.
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