Limited information is available for the S requirements of higher yielding winter wheat (Triticum aestivumL.) crops grown in the eastern United States. Three experiments were conducted in the Coastal Plain region of Virginia on Kenansville loamy sand (loamy, siliceous, thermic Arenic Hapludult), Dothan loamy sand (fine‐loamy, siliceous, thermic Plinthic Paleudult), and Pactolus loamy sand (thermic, coated Aquic Quartzipsamment) soils. These three soils have low monocalcium phosphate‐acetic acid extractable SO4‐S (<3.1 kg/ha) and would be expected to be S deficient With respect to corn (Zea maysL). Winter wheat response to S application was investigated on the Kenansville and Dothan soils, while the N x S interaction was studied on the Pactolus soil. In the two studies where S was the dependent variable there was no significant change in concentration of the flag leaf at Feekes growth stage 10 for N, S, P, K, Ca, Mg, and N/S ratio. Also yields were not significantly influenced by S application and averaged 5.6 Mg/ha for the Kenansville and 4.3 Mg/ha for the Dothan soils. In the N x S interaction study, yield increased linearly with increased N application, and N and P tissue concentrations were increased with N application. These data indicate that S concentrations of 0.20% and a N/S ratio of 18 in the flag leaf at Feekes growth stage 10 is sufficient for high yields. The absence of S deficiency in these relatively high‐yielding experiments on coarse textured soils with low levels of extractable SO4‐S may be related to atmospheric accretions during much of the wheat growing season.