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High Performance Liquid Chromatography of Isoxazolyl-Naphthoquinones: A Comparison Between Experimental and Theoretical Lipophilicity

 

作者: Marcela Longhi,   Marcela Linares,   MaríaM. de Bertorello,  

 

期刊: Journal of Liquid Chromatography & Related Technologies  （Taylor Available online 1996）
卷期: Volume 19, issue 12  

页码: 1947-1956

 

ISSN:1082-6076

 

年代: 1996

 

DOI:10.1080/10826079608014018

 

出版商: Taylor & Francis Group

 

数据来源: Taylor

 

摘要:

An RP-HPLC procedure was developed for determining the lipophilicity of a series of isoxazolyl-naphthoquinones which possess antibacterial, trypanosidal and antineoplasic activity. The experimental results were compared with theoretical log P values, and it was found that there was a good relationship between the two methods, except for very lipophilic compounds.

 

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