Responsiveness of Murine Lymphokine-Activated Killer Activity to Prostaglandin E2at Late Phase of lnterleukin-2 Induction
作者:
Shuhei Kokudo,
T. Ming Chu,
期刊:
Tumor Biology
(Karger Available online 1993)
卷期:
Volume 14,
issue 3
页码: 144-154
ISSN:1010-4283
年代: 1993
DOI:10.1159/000217830
出版商: S. Karger AG
关键词: Cyclic adenosine monophosphate;Lymphokine-activated killer activity;Interleukin-2;Prostaglandin E2
数据来源: Karger
摘要:
To elucidate the inhibitory effect of prostaglandin E2 (PGE2) on the generation of recombinant interleukin-2 (IL-2)-induced lymphokine-activated killer (LAK) activity, we have examined the association between cellular 3′,5′-cyclic adenosine monophosphate (cAMP) and cytolytic activity of 3-day IL-2-cultured murine LAK cells, i.e. at late phase of IL-2 induction, in the presence and absence of PGE2. The results indicate that, at the late phase of IL-2 induction, LAK cells retain their responsiveness to PGE2 inhibition, and the inhibition can be partially suppressed by additional IL-2 in proportion to the decrease in the ratios of stimulated to basal cellular cAMP lev
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