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Genetic linkage and complex diseases, with special reference to psychiatric disorders

 

作者: Neil Risch,   D. C. Rao,  

 

期刊: Genetic Epidemiology  （WILEY Available online 1990）
卷期: Volume 7, issue 1  

页码: 3-16

 

ISSN:0741-0395

 

年代: 1990

 

DOI:10.1002/gepi.1370070103

 

出版商: Wiley Subscription Services, Inc., A Wiley Company

 

关键词: schizophrenia;genetic heterogeneity;epistasis;phenotypic variation

 

数据来源: WILEY

 

摘要:

AbstractRecent linkage findings for psychiatric disorders, in particular schizophrenia, manic‐depression, and Alzheimer disease, have raised a number of important conceptual issues regarding the genetic etiology of these diseases, as well as the appropriate interpretation of linkage results in studying complex diseases. Perspectives on mode of inheritance, genetic heterogeneity, and phenotypic variation are give

 

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