PLATELET CROSSMATCHING FOR KIDNEY TRANSPLANTS BY FLOW CYTOMETRY
作者:
GUIXI WANG,
GLENN TERASHITA,
PAUL TERASAKI,
期刊:
Transplantation
(OVID Available online 1989)
卷期:
Volume 48,
issue 6
页码: 959-961
ISSN:0041-1337
年代: 1989
出版商: OVID
数据来源: OVID
摘要:
Although flow cytometry crossmatching is now per formed by many kidney transplant centers, it yields a high false-positive rate, as evidenced in the present series by a 71 % one-month success rate despite a positive crossmatch. In an attempt to reduce false-positive re actions while retaining the sensitivity of the flow cytometer, platelets were tested as targets. Whereas flow cytometry with T cells was not correlated with one-month failure rates, retrospective platelet crossmatching by flow cytometry showed that kidney failure within one month occurred in 53% of 19 patients with a positive platelet crossmatch compared with 15% of 48 patients with a negative platelet crossmatch. (P<0.002). Statistical significance in one-month outcome was also obtained when only first transplant patients were analyzed (P< 0.04). The present results suggest that crossmatching with platelet targets may be a simpler way to avoid early primary nonfunction while minimizing false-positive reactions.
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