Polyunsaturated Fatty Acids in Hyperlipoproteinemia
作者:
Ulf Svanberg,
Anders Gustafson,
Ragnar Ohlson,
期刊:
Annals of Nutrition and Metabolism
(Karger Available online 1974)
卷期:
Volume 17,
issue 6
页码: 338-346
ISSN:0250-6807
年代: 1974
DOI:10.1159/000175557
出版商: S. Karger AG
关键词: Serum triglycerides;Man;Phosphoglycerides;Lecithin;α-Lipoprotein;Linoleic acid
数据来源: Karger
摘要:
The daily oral administration of 2 mM (1,700 mg) lecithin linoleate, as Lipostabil®, to five males with hypertriglyceridemia, caused after 5 weeks a mean increase (p < 0.05) of α-lipoproteins (measured as cholesterol content), a mean increase in relative linoleic acid (18:2) content of α-lipoprotein phosphoglycerides and a tendency to serum triglyceride reduction (by 16 %). Linoleic acid containing α-lipoprotein phosphoglycerides (estimated on absolute amounts) were inversely related (r = -0.68; p < 0.001) to log serum triglyceride values. It is suggested that one beneficial effect of linoleic acid (and lecithin linoleate) in hypertriglyceridemia might be mediated through an increase in α-lipoproteins and specifically in α-lipoprotein lecithin linoleic acid, i.e. a substrate in the lecithin:cholesterol acyl transferase (LCAT) rea
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