Pathology of the kidney in “toxic oil epidemic syndrome”
作者:
JoséJ. Navas‐Palacios,
Gabriel Usera‐Sárraga,
Ricardo Gil‐Martin,
Victor Gutierrez‐Millet,
期刊:
Journal of Toxicology and Environmental Health
(Taylor Available online 1984)
卷期:
Volume 13,
issue 1
页码: 1-18
ISSN:0098-4108
年代: 1984
DOI:10.1080/15287398409530477
出版商: Taylor & Francis Group
数据来源: Taylor
摘要:
In May 1981, a massive intoxication of people who had ingested adulterated cooking oil took place in Madrid and nearby provinces. Although the patients presented, in the first phase of the disease, with acute respiratory illness, later on thromboembolic com‐plications, severe neuromuscular involvement, and scleroderma‐like cutaneous lesions appeared. Kidneys were apparently spared; however, 4 out of 842 admitted patients developed glomerulonephritis; kidney biopsies revealed glomerular, vascular, tubular, and interstitial changes. Cases 1 and 3 had diffuse proliferative endocapillary glomerulonephritis; case 2 had diffuse membranoproliferative glomerulonephritis; and case 4 had diffuse extracapillary glomerulonephritis. Three cases had vasuclar lesions characterized by degenerative and proliferative endothelial changes, intimai foamy macrophages, and partial or complete obliteration of the vascular lumen by concentric myxoid fibrosis. There were signs of necrosis of tubular epithelium along with edema and lymphocytic and eosinophilic interstitial infiltration. Two out of 22 autopsies had segmentary glomerulonephritis, and 17 out of 22 autopsies showed renal vascular lesions.
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