CRH Defects in Alzheimer's and Other Neurologic Diseases
作者:
SouzaErrol B. De,
期刊:
Hospital Practice
(Taylor Available online 1988)
卷期:
Volume 23,
issue 9
页码: 59-71
ISSN:2154-8331
年代: 1988
DOI:10.1080/21548331.1988.11703535
出版商: Taylor&Francis
数据来源: Taylor
摘要:
The demonstration of an upregulation of CRH receptors in the cerebral cortex after a decrease in cortical CRH content in Alzheimer's disease indicates the physiologic relevance of the receptor site. It is consistent with the concept that CRH acts as a neurotransmitter in normal cortical functions and that disease of this peptidergic system may be important in certain manifestations of dementia.
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