7,8 Dihydroneopterin Inhibits Low Density Lipoprotein Oxidation in Vitro. Evidence That This Macrophage Secreted Pteridine is an Anti-Oxidant
作者:
GiesegSteven P.,
ReibneggerGilbert,
WachterHelmut,
EsterbauerHermann,
期刊:
Free Radical Research
(Taylor Available online 1995)
卷期:
Volume 23,
issue 2
页码: 123-136
ISSN:1071-5762
年代: 1995
DOI:10.3109/10715769509064027
出版商: Taylor&Francis
关键词: neopterin;7,8 dihydroneopterin;low-density lipoprotein;copper oxidation;antioxidant;peroxyl radical
数据来源: Taylor
摘要:
Neopterin and its reduced form, 7,8 dihydroneopterin afe pteridines released from macrophages and monocytes when stimulated with interferon gammain vivo.The function of this response is unknown though there is an enormous amount of information available on the use of these compounds as clinical markers of monocyte/macrophage activation. We have found that in vitro 7,8-dihydroneopterin dramatically increases, in a dose dependent manner, the lag time of low density lipoprotein oxidation mediated by Cu++ions or the peroxyl radical generator 2,2′-azobis (2-amidino propane) dihydrochloride (AAPH). 7,8-Dihydroneopterin also inhibits AAPH mediated oxidation of linoleate. The kinetic of the inhibition suggests that 7,8-dihydroneopterin is a potent chain breaking antioxidant which functions by scavenging lipid peroxyl radicals. No anti-oxidant activity was observed in any of the oxidation systems studied with the related compounds neopterin and pterin.
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