Hypoxanthine and Oxygen Induced Lung InjuryA Possible Basic Mechanism of Tissue Damage?
作者:
O. SAUGSTAD,
M. HALLMAN,
J. ABRAHAM,
B. EPSTEIN,
C. COCHRANE,
L. GLUCK,
期刊:
Pediatric Research
(OVID Available online 1984)
卷期:
Volume 18,
issue 6
页码: 501-503
ISSN:0031-3998
年代: 1984
出版商: OVID
数据来源: OVID
摘要:
Lung injury was induced in young rats by a continuous infusion of hypoxanthine intravenously and breathing 100% oxygen for 48 h (group 1). Control animals were rats infused glucose and breathing 100% oxygen (group 2), rats infused hypoxanthine in room air (group 3), and untreated rats (group 4). In group 1 rats interstitial and alveolar edema was found with a tendency toward marked margination of polymorphonuclear neutrophils in small vessels (P< 0.025 compared with group 2). The main elastase inhibitor alpha,-antitrypsin (α-l-PI) was significantly elevated in group 1; 2-, 3− and 5-fold, respectively, when compared with groups 2, 3, and 4. The surfactant phopholipids from alveolar lavage were normal in all groups. The protein-rich fraction of the lavage fluid from group 1 rats inactivated, however, the surface properties of lung surfactant. Minimum surface tension in group 1 rats was 14.5 dyn/cm compared with 7.0 dyn/cm in group 2, 2.9 dyn/cm in group 3 and 3.5 dyn/cm in group 4 (P < 0.05, group 1 and 2versus4). We conclude that the combination of hypoxanthine and high levels of oxygen causes lung injury, possibly via free oxygen radicals. We discuss the possibility that these findings demonstrate a basic pathogenetic mechanism for the hypoxic-hyperoxic insult and can contribute to the understanding of pathogenesis of a variety of diseases both in pediatrics and adult medicine.
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