The Clinical Profile of Sumatriptan: Cluster Headache
作者:
Peter J. Goadsby,
期刊:
European Neurology
(Karger Available online 1994)
卷期:
Volume 34,
issue 2
页码: 35-39
ISSN:0014-3022
年代: 1994
DOI:10.1159/000119530
出版商: S. Karger AG
关键词: Sumatriptan;Cluster headache;Clinical trials;Migraine
数据来源: Karger
摘要:
Cluster headache is a rare form of severe idiopathic headache characterized by unilateral short-lasting episodes of excruciating pain in association with autonomic disturbances. Subcutaneous sumatriptan has been investigated as an acute treatment for cluster headache in two randomized, double-blind, placebo-controlled, crossover trials. About 75% of patients given subcutaneous sumatriptan 6 mg reported headache relief within 15 min, in comparison with 26-35% given placebo (p < 0.001 in both studies). The need for rescue medication (100% oxygen by inhalation) at 15 min was significantly lower after sumatriptan treatment as were the severity of functional disability and incidence of non-headache symptoms. Results of a long-term study indicate that the tolera-bility and efficacy of sumatriptan 6 mg is maintained in long-term use, and that there is no evidence of tachyphylaxis.
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