Direct inhibitory effect of taurine on relay neurones of the rat olfactory bulbin vitro
作者:
Michelino Puopolo,
Igor Kratskin,
Ottorino Belluzzi,
期刊:
NeuroReport
(OVID Available online 1998)
卷期:
Volume 9,
issue 10
页码: 2319-2323
ISSN:0959-4965
年代: 1998
出版商: OVID
关键词: Inhibition;Mitral/tufted cells;Olfactory bulb;Patch-clamp;Rat;Slice preparation;Taurine
数据来源: OVID
摘要:
WHOLE-CELL recordings in rat olfactory bulb slices showed that bath application of 5 mM taurine produces a potent and reversible inhibition of identified mitral and tufted cells. Under current-clamp conditions, a shift of the membrane potential toward the chloride equilibrium potential and a 75% reduction in the membrane resistance were observed. These effects were strongly blocked by bicuculline (10 μM), but not by GABABantagonist and strychnine, and completely maintained under the blockage of synaptic transmission. The results suggest that inhibition of bulbar relay neurons produced by taurine is primarily due to direct activation of somatic GABAAreceptors and initiation of chloride conductance. This study demonstrates for the first time the actions of taurine in the olfactory system.
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