The Role of DNA Testing in Breast, Ovarian, and Colon Cancers
作者:
Christopher Friedrich,
期刊:
The American Journal of the Medical Sciences
(OVID Available online 2003)
卷期:
Volume 325,
issue 3
页码: 120-124
ISSN:0002-9629
年代: 2003
出版商: OVID
关键词: Colon cancer;Breast cancer;Cancer susceptibility genes;Genes;Genetics
数据来源: OVID
摘要:
A proportion of cases of breast and colon cancers are caused by inherited mutations that confer a greatly increased susceptibility to malignancy. Certain clinical features may help distinguish patients with a genetic cause for their cancer from the larger number of patients with sporadic tumors. A thorough family medical history is also necessary to identify those at high risk for developing cancer. Many of the normal functions of these genes are understood, and mutation analysis for patients and their families is now available as a clinical service. Presymptomatic detection of mutations allows the patient to pursue preventive measures to reduce the probability of developing a malignancy. Evidence is now available that some prophylactic measures do reduce the incidence of cancer and reduce mortality in mutation carriers, and the standard of care is evolving rapidly. The essential elements necessary to provide accurate interpretations of molecular genetics test results to patients are described.
点击下载:
PDF
(120KB)
返 回