Immunogenicity of a Recombinant Hepatitis B Vaccine in Hemodialysis Patients: A Two-Year Follow-Up
作者:
D. Docci,
P.A. Cipolloni,
S. Mengozzi,
L. Baldrati,
C. Capponcini,
C. Feletti,
期刊:
Nephron
(Karger Available online 1992)
卷期:
Volume 61,
issue 3
页码: 352-353
ISSN:1660-8151
年代: 1992
DOI:10.1159/000186939
出版商: S. Karger AG
关键词: Hemodialysis;Hepatitis B vaccination;Recombinant hepatitis B vaccine
数据来源: Karger
摘要:
The immunogenicity of a recombinant hepatitis B vaccine was evaluated in 35 hemodialysis patients who received a standard dose (20 μg) of the vaccine at 0,1, 2 and 6 months. After the full vaccination course (month 7), 60% (21/35) of the patients had seroconverted (anti-HBs titer ≥10 mlU/ml). The duration of protection lasted up to 18 months after the start of vaccination in 85.7% (18/21) of the responders. At that time, an additional dose was given to all the patients: 1-2 months later, the overall immunization rate had increased to 65.7% (23/35); lastly, in month 24 (i.e., 6 months after the booster dose), 62.5% (15/24) of the patients available for evaluation were still maintaining protective levels of anti-HBs antibodies. Comparable results had previously been obtained in 21 well-matched patients on our dialysis program who were vaccinated with a plasma-derived vaccine according to the recommended schedu
点击下载:
PDF
(350KB)
返 回