Functional Comparison Between HTLV‐I Envelopes Originating from TSP/HAM or ATL Cell Lines
作者:
Claudine Pique,
Fortuna Saal,
Jorge Périès,
Danièle Pham,
Thomas Tursz,
Marie-Christine Dokhélar,
期刊:
Journal of Acquired Immune Deficiency Syndromes
(OVID Available online 1994)
卷期:
Volume 7,
issue 4
页码: 319-324
ISSN:0894-9255
年代: 1994
出版商: OVID
关键词: Human T-cell leukemia virus type I (HTLV-I);Adult T-cell leukemia;Tropical spastic paraparesis/HTLV-I-associated myelopathy;Syncytium formation;Envelope.
数据来源: OVID
摘要:
SummaryThe human T-cell leukemia type I (HTLV-I) virus is associated with two different diseases, adult T-cell leukemia (ATL) and tropical spastic para-paresis/HTLV-I-associated myelopathy (TSP/HAM). We have compared the viral envelopes originating from TSP/HAM and ATL patients, using the capacity of infected cells to form syncytia with receptor-expressing cells. We show that like the ATL cell lines, the TSP/HAM ones can form syncytia with a large panel of human target cells, including a variety of hematopoietic cell lines, as well as cell lines of neuroectodermal origin. None of the target cell lines tested was able to discriminate between TSP/HAM- and ATL-infected cell lines. When infected cells of TSP/HAM origin are cocultivated with cells of ATL origins, syncytia are never observed. This interference phenomenon suggests that the viruses expressed by the different cell lines utilize the same receptor.
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