Autoimmunity, HLA, Gm AND Km Polymorphisms in Turner's Syndrome
作者:
LarizzaD.,
BianchiM. Martinetti,
LoriniR.,
MaghnieM.,
DugoujonJ. M.,
BelvedereM. Cuccia,
SeveriF.,
期刊:
Autoimmunity
(Taylor Available online 1989)
卷期:
Volume 4,
issue 1-2
页码: 69-78
ISSN:0891-6934
年代: 1989
DOI:10.3109/08916938909034361
出版商: Taylor&Francis
关键词: Turner's syndrome;autoimmunity;HLA polymorphisms;Gm and Km allotypes
数据来源: Taylor
摘要:
Considering the high frequency of autoimmune disorders in Turner's syndrome and the close relationship between autoimmunity, HLA and immunoglobulin constant region gene polymorphisms, we studied 46 patients with Turner's syndrome, by determination of autoantibodies, HLA histoglobulins and Gm and Km allotypes. OSA and in particular PCA resulted significantly more frequent in patients than in the controls. A higher frequency of HLA-A31, B38 antigens and of blanks at HLA-A locus was found in Turner's subjects than in the controls. A31 was significantly more frequent in autoantibody positive patients while B38 was more frequent in autoantibody negative Turner's subjects than in the controls. DR4 antigen was present only in autoantibody negative patients. Gm 3; 23; 5* phenotype was significantly less frequent, while Gm 3; 5* phenotype was more frequent in patients than in controls. Our data confirm the higher incidence of autoimmunity disorders in Turner's syndrome than in normal subjects. Particular HLA and immunoglobulin types seem to mark this condition. The increase in the blank frequency at A locus could be explained by the presence of a rare antigen at HLA-A locus or a particularly elevated homozygous condition in these subjects.
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