Nerve Growth Factor Receptor-like Immunoreactivity in the Human Spinal Cord
作者:
J.M. Kerwin,
C.M. Morris,
R.H. Perry,
E.K. Perry,
期刊:
Cells Tissues Organs
(Karger Available online 1992)
卷期:
Volume 144,
issue 4
页码: 348-353
ISSN:1422-6405
年代: 1992
DOI:10.1159/000147329
出版商: S. Karger AG
关键词: Immunocytochemistry;Spinal cord;Nerve growth factor receptor;Motor neuron disease
数据来源: Karger
摘要:
Nerve growth factor (NGF) receptor-like immunoreactivity has been demonstrated in the normal human adult spinal cord using the monoclonal antibody ME20.4. Intense immunoreactivity was associated with fibres and terminals in the substantia gelatinosa. In lamina IX the neuropil demonstrated punctate staining, the motor neurons themselves being negative. At thoracic levels occasional neurons of the intermediolateral column cell group were NGF receptor positive. Fine axonal and punctate terminal reactivity was observed in the gracile fasciculus, corresponding to axons in transverse section. Similar, though slightly less dense immunoreactivity was observed in the cuneate fasciculus. The demonstration of NGF receptor immunoreactivity may provide a useful marker of sensory innervation in the human spinal cord.
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