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Clinical Pharmacokinetics of Isoniazid

 

作者: Wendell W. Weber,   David W. Hein,  

 

期刊: Clinical Pharmacokinetics  (ADIS Available online 1979)
卷期: Volume 4, issue 6  

页码: 401-422

 

ISSN:0312-5963

 

年代: 1979

 

出版商: ADIS

 

数据来源: ADIS

 

摘要:

The pharmacokinetics of isoniazid in man are described. Pronounced interindividual variation in circulating isoniazid concentration and clearance which occur after dosing with the drug are associated with hereditary differences in the acetylator status. The variations in rate of isoniazid inactivation and elimination in different (rapid and slow) acetylator phenotypes are primarily due to differences in the rate of acetylation of isoniazid by a genetically controlled polymorphic N-acetyltransferase in liver and small intestine. An appreciable ‘first-pass’ effect is observed following oral isoniazid administration, particularly in the rapid acetylator phenotype.Liver disease can cause a significant prolongation in the clearance of isoniazid; in the acutely ill patient, the prolongation correlates most closely with serum bilirubin elevation, although the degree of prolongation is less important than the intrinsic genetic difference between acetylator phenotypes. The effect of renal impairment on isoniazid excretion is relatively unimportant, even in slow acetylators.Methods for monitoring blood and urine concentrations of isoniazid and for acetylator phenotype determination which are convenient for the patient and clinician are available. Implications of phenotypic differences in acetylator status for the optimal management of tuberculosis with isoniazid are considered. Attempts to devise new isoniazid formulations for this purpose are being evaluated.

 

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