The Association of HLA-B5 Antigen with Specific Manifestations of Behçet’s Disease
作者:
G. Azizlerli,
V.L. Aksungur,
R. Sanca,
E. Akyol,
C. Övül,
期刊:
Dermatology
(Karger Available online 1994)
卷期:
Volume 188,
issue 4
页码: 293-295
ISSN:1018-8665
年代: 1994
DOI:10.1159/000247169
出版商: S. Karger AG
关键词: Behçet’s disease;HLA-B5 antigen
数据来源: Karger
摘要:
The HLA-B5 phenotype was investigated in 235 patients with Behçet’s disease and in 100 healthy persons. HLA-B5 was more frequent in the patients (77 vs. 30% p < 0.001, relative risk = 7.8). The frequency of HLA-B5 was higher in patients with genital ulceration than without (82.3 vs. 63%, p < 0.01). Patients with thrombophlebitis showed a less frequent positivity of HLA-B5 antigen than the patients without thrombophlebitis (50 vs. 79.2%. p < 0.02). These results suggest that HLA-B5-related genes not only affect the development of Behçet’s disease but also the occurrence of its clinical manifesta
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