DNA Flow-Cytometric Analysis of Basal Cell Carcinomas and Its Relevance to Their Morphological Differentiation: A Retrospective Study
作者:
M. Fortier-Beaulieu,
A. Laquerrière,
E. Thomine,
P. Lauret,
J. Hémet,
期刊:
Dermatology
(Karger Available online 1994)
卷期:
Volume 188,
issue 2
页码: 94-99
ISSN:1018-8665
年代: 1994
DOI:10.1159/000247109
出版商: S. Karger AG
关键词: Human basal cell carcinomas;Morphological differentiation;Flow cytometry;DNA index;Cytokinetics
数据来源: Karger
摘要:
DNA flow cytometry (FCM) was performed on archived material of 82 basal cell carcinomas (BCC), using Hedley’s technique. Sixty-five samples were analysed. Biopsy samples were classified in five groups depending on their morphological differentiation: solid, cystic, adenoid, keratotic andmetatypical. Two parameters were studied: proliferative index and DNA index. Statistical analysis revealed that BCC with keratinizing or metatypical differentiation had a greater amount of aneuploidy when compared with BCC without particular differentiation (solid and cystic) or aneuploid differentiation (p < 0.001). The proliferative indices were significantly different in the four groups. DNA FCM of BCC confirms the value of morphological classifications and gives another example of aneuploidy in a tumour with low aggressivenes
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