Increased Serum and mRNA Levels of RANTES Associated with Elevated Levels of Activated CD8+CD38+ T Cells in HIV-1-Infected Individuals
作者:
Peter Müller,
Martin Engelstädter,
Albrecht Werner,
Jens Braner,
Schlomo Staszewski,
Veronica Miller,
Hans-Wilhelm Doerr,
Reinhard Kurth,
Klaus Cichutek,
期刊:
Intervirology
(Karger Available online 1997)
卷期:
Volume 40,
issue 4
页码: 263-270
ISSN:0300-5526
年代: 1997
DOI:10.1159/000150556
出版商: S. Karger AG
关键词: Activation;Chemokines;IL-16;CDA;CD8;CD38;Cellular factors/cytokines;Disease progression;Anti-viral therapy
数据来源: Karger
摘要:
The serum levels of the β-chemokine RANTES and, albeit less, MIP-1β were found to be increased in 37 HIV-1 infected compared to seronegative individuals. In contrast the serum levels of IL-16 were only sporadically elevated in seropositives as well as in seronegatives. Concomitantly, the RANTES gene expression increased about tenfold in seropositives, whereas the MIP-1β and IL-16 mRNA levels were not elevated. No correlation between the increase of the MlP-1β and RANTES serum concentrations and the plasma virus load, the number of the peripheral CD4+ T cells or the therapy status of the patients was found. However, the increased proportion of activated CD8+CD38+ T cells in the peripheral blood of all seropositives paralleled the increased RANTES serum levels detected indicating that immune activation in HIV-1-infected individuals may contribute to increased RANTES serum lev
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