Influence of Age on the Thyroid Hormone-Induced Up-Regulation of β-Adrenoceptors in Mouse Brain Cortex
作者:
C. Viticchi,
R. Grinta,
L. Piantanelli,
期刊:
Gerontology
(Karger Available online 1990)
卷期:
Volume 36,
issue 5-6
页码: 286-292
ISSN:0304-324X
年代: 1990
DOI:10.1159/000213213
出版商: S. Karger AG
关键词: Thyroid hormones;Brain cortex;β-Adrenoceptors;Receptor up-regulation
数据来源: Karger
摘要:
The influence of ageing on the ability of the brain cortex β-adrenoceptors to be regulated by very short stimulation with thyroid hormones has been investigated. Experiments were performed in 3-, 10-, 17- and 22-month-old mice using both thyroxine (T4) and triiodothyronine (T3) as stimulators and analyzing β-adrenergic receptor characteristics 15 and 60 min after hormone injection. Results showed that a statistically significant up-regulation is present in both young and old mice when treated with T3. On the contrary, after T4 injection only 3-month-old animals respond to such a short-term treatment, whereas older adult and old animals showed not statistically significant changes. Thus, the impairment in the T4-induced up-regulation starts already in adult mice and does not seem to further increase progressively with advancing age. From these findings it is suggested that the lack of responsiveness of β-adrenoceptors to T4 but not to T3 stimulation in adult and old mice may be due to relatively early impairment in the transformation of T4 into T3
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