National Surveillance of HIV-1 Subtypes for England and WalesDesign, Methods, and Initial Findings
作者:
John Parry,
Gary Murphy,
Katrina Barlow,
Kim Lewis,
Pauline Rogers,
Francisco Belda,
Angus Nicoll,
Christine McGarrigle,
Susan Cliffe,
Philip Mortimer,
Jonathan Clewley,
期刊:
JAIDS Journal of Acquired Immune Deficiency Syndromes
(OVID Available online 2001)
卷期:
Volume 26,
issue 4
页码: 381-388
ISSN:1525-4135
年代: 2001
出版商: OVID
关键词: Heterosexual transmission;HIV-1 subtypes;Molecular epidemiology;Surveillance
数据来源: OVID
摘要:
The HIV-1 infections detected in an ongoing national unlinked anonymous HIV surveillance program were subtyped and analyzed according to demographic and risk characteristics. Of the 893 anti–HIV-1–positive specimens allocated to an exposure group, 70% could be subtyped. Almost 25% of infections subtyped were non-B, mostly subtypes A, C, and D. Non-B infections were rare in homosexual and bisexual men and in drug injectors. Forty percent of infections in heterosexual men attending genitourinary medicine clinics were non-B subtypes; of these, 25% were subtype A infections and 59% were subtype C infections. For female clinic attendees, 61% were non-B subtype infections, of which 48% were subtype A infections and 42% were subtype C infections. Of the clinic attendees born in the United Kingdom and Europe, 14% of the men and 35% of the women were infected with non-B subtypes. In contrast, 78% of infections in antenatal patients were non-B subtypes, of which 61% were subtype A and 29% were subtype C. Extrapolation to the estimated 29,700 prevalent adult infections in the United Kingdom indicates that approximately 8,100 (27%) such infections are non-B subtypes and that these are found almost entirely in heterosexuals. The findings suggest spread of infection of non-B subtypes to heterosexuals born in the United Kingdom from individuals infected in regions of high prevalence.
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