Two cultivars of cotton (Gossypiumspp) were grown in Yolo loam soil in a glasshouse to determine phytotoxicity effects of Cr and Li and possible interactions with other metals. The Cr at 100μg/g soil had no adverse effects on either cultivar studied. A Cr increase was not observed in either stems or leaves. Both cultivars tolerated 25 and 50μg Li/g soil. The 50μg Li/g soil resulted in leaves of Acala SJ‐2 with 432μg Li/g leaves and 720 in Giza 45. The 100μg Li/g soil resulted in 74% and 87% leaf yield reductions in Acala SJ‐2 and Giza 45 respectively. Leaf concentrations of Li respectively were 1950 and 1850μg/g. Except at the highest level of Li, leaves had higher concentrations of Li than did roots. The Cr and Li resulted in some plant metal interactions.