Treatment of hyperlipidemia in chronic progressive renal disease
作者:
Bertram Kasiske,
Michael O'Donnell,
Youngki Kim,
William Keane,
期刊:
Current Opinion in Nephrology and Hypertension
(OVID Available online 1993)
卷期:
Volume 2,
issue 4
页码: 602-608
ISSN:1062-4821
年代: 1993
出版商: OVID
数据来源: OVID
摘要:
Experiments in animal models suggest that correcting abnormalities in lipid metabolism could help slow the rate of functional decline in patients with chronic progressive renal disease. Circumstantial evidence in humans also suggests that lipids may play a role in the pathogenesis of glomerulosclerosis. Nevertheless, large controlled clinical trials examining the effect of lipid-lowering strategies on renal disease progression have not been carried out. However, the recent development of antilipemic agents that appear to be safe and effective in patients with renal disease should make it possible to determine whether treating hyperlipidemia will reduce the rate of renal disease progression.
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