Comparative Effects of Dopexamine and Dopamine on Glycerol-Induced Acute Renal Failure in Rats
作者:
GómezDulce Nombre,
LópezAntonio,
ElenoNélidacute;,
LópezJosÉM.,
期刊:
Renal Failure
(Taylor Available online 1996)
卷期:
Volume 18,
issue 1
页码: 59-68
ISSN:0886-022X
年代: 1996
DOI:10.3109/08860229609052774
出版商: Taylor&Francis
关键词: Acute renal failure;Diuresis;Dopamine;Dopexamine hydrochloride;Glomerular filtration rate;Glycerol;Renal blood flow;Renal function
数据来源: Taylor
摘要:
Acute renal failure (ARF) was induced in rats by intramuscular injection of 50% glycerol, 10 mL/kg body weight. Rats were given isotonic saline (1.5 mL/h) dopexamine hydrochloride (dopexamine, 100μg/h) or dopamine (100μg/h), commencing either immediately after glycerol administration and maintained during all the observation time (90 min, acute studies) or 20 min before administration of glycerol and during 60 min (chronic studies). Renal function was assessed during 90 min after induction of ARF in anesthetized rats and during 3 days following ARF induction in conscious animals. In anesthetized rats treated with dopexamine or dopamine, the reduction in inulin and para-aminohippuric acid clearance was markedly lower than that observed in untreated animals. In conscious animals, urinary flow and creatinine clearance were higher in rats treated with dopamine or dopexamine than in the non-treated group. Rats treated with dopexamine had higher renal Na+and K+excretion than dopamine-treated rats. Survival was higher in the dopexamine group than in either of the other two groups. These results demonstrate that pretreatment with dopexamine or dopamine significantly improves the course of ARF, with better survival after treatment with dopexamine.
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