Role of serotonin in the amygdala in hypothalamo‐pituitaryadrenocortical responses
作者:
Shaul Feldman,
Michael Newman,
Eitan Gur,
Joseph Weidenfeld,
期刊:
NeuroReport
(OVID Available online 1998)
卷期:
Volume 9,
issue 9
页码: 2007-2009
ISSN:0959-4965
年代: 1998
出版商: OVID
关键词: ACTH;Amygdala;Corticosterone;CRH-41;Hypothalamus;Serotonin
数据来源: OVID
摘要:
IN view of the fact that the amygdala (AMG) and hypothalamic serotonin (5-HT) have an excitatory effect on the hypothalamo-pituitary-adrenal (HPA) axis, we have investigated the role of 5-HT in the AMG on this response. In intact freely moving rats, a mildly stressing short photic stimulation caused depletion of median eminence CRH-41, due to its release into the portal circulation and a rise in serum ACTH and corticosterone levels. This effect was significantly inhibited in rats in which 5-HT was depleted in the AMG following local 5,7-dihydroxytryptamine administration, which did not affect hypothalamic 5-HT content. Also, local pretreatment with ketanserin (a 5-HT2receptor antagonist) in the AMG had the same inhibitory effect on the HPA axis response. These results indicate that AMG 5-HT has an important role in the activation of the HPA axis following neural stimulation and that 5-HT2receptors are involved.
点击下载:
PDF
(333KB)
返 回