Influence of Immunosuppression on the Action of Antimycohacterial Drugs in Experimental Tuberculosis
作者:
Ludek Trnka,
Marie Kvapilová,
Peter Mišoň,
期刊:
Chemotherapy
(Karger Available online 1976)
卷期:
Volume 22,
issue 6
页码: 353-361
ISSN:0009-3157
年代: 1976
DOI:10.1159/000221947
出版商: S. Karger AG
关键词: Experimental chemotherapy;Experimental tuberculosis;Azathioprine;Immunosuppression;Isoniazid;Rifampicin;Streptomycin
数据来源: Karger
摘要:
The influence of the host immunosuppression on antimycobacterial effects of isoniazid, rifampicin or streptomycin was studied on animal models. Differences in survival rates of mice influenced or uninfluenced by azathioprine (Imuran) and exposed to six applications of antituberculous drugs (given once a day in the monotherapy) were statistically evaluated. The dose-dependent antimycobacterial effects of rifampicin or isoniazid were not significantly altered by the immunosuppression of the host. In contrary to that definite dose-dependent effect of streptomycin, observed in azathioprine-uninfluenced mice, cannot be confirmed in immunosuppressed mice in which no effect of streptomycin on the survival of tuberculous mice could be estimated.
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