AROMATICl‐AMINO ACID DECARBOXYLASE: HISTOCHEMICAL LOCALIZATION IN RAT KIDNEY AND LACK OF EFFECT OF DIETARY POTASSIUM OR SODIUM LOADING ON ENZYME DISTRIBUTION
作者:
William R. Adam,
Anne J. Culvenor,
John Hall,
Bevyn Jarrott,
R. Mark Wellard,
期刊:
Clinical and Experimental Pharmacology and Physiology
(WILEY Available online 1986)
卷期:
Volume 13,
issue 1
页码: 47-53
ISSN:0305-1870
年代: 1986
DOI:10.1111/j.1440-1681.1986.tb00314.x
出版商: Blackwell Publishing Ltd
关键词: aromaticl‐amino acid decarboxylase;dopamine;immunohistochemistry;l‐dopa;potassium;rat kidney;sodium.
数据来源: WILEY
摘要:
SUMMARY1. Utilizing a mono‐specific antiserum produced in rabbits to hog kidney aromaticl‐amino acid decarboxylase (AADC), the enzyme was localized in rat kidney by immunoperoxidase staining.2. AADC was located predominantly in the proximal convoluted tubules; there was also weak staining in the distal convoluted tubules and collecting ducts.3. An increase in dietary potassium or sodium intake produced no change in density or distribution of AADC staining in kidney.4. An assay of AADC enzyme activity showed no difference in cortex or medulla with chronic potassium loading.5. A change in distribution or activity of renal AADC does not explain the postulated dopaminergic modulation of renal function that occurs with potassium or sodium load
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