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Synthesis of high specific activity [15,16‐3H2]buprenorphine

 

作者: Ferenc Ötvös,   Sándor Hosztafi,   Csaba Simon,   Géza Tóth,  

 

期刊: Journal of Labelled Compounds and Radiopharmaceuticals  （WILEY Available online 1995）
卷期: Volume 36, issue 1  

页码: 79-83

 

ISSN:0362-4803

 

年代: 1995

 

DOI:10.1002/jlcr.2580360110

 

出版商: John Wiley&Sons, Ltd.

 

关键词: tritiation;buprenorphine;15,16‐didehydrobuprenorphine;opioid ligand

 

数据来源: WILEY

 

摘要:

AbstractTritium labelling of buprenorphine, a mixed agonist‐antagonist opioid ligand, was performed with a specific activity of 2.35 TBq/mmol (63.6 Ci/mmol) starting with 15,16‐didehydrobuprenorphine. Labels at positions 15 and 16 of the morphine skeleton proved to be sufficiently stable under strong acidic or basic conditi

 

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