Cough Reflex Threshold in Diabetes mellitus with and without Autonomic Neuropathy
作者:
D. Behera,
S. Das,
R.J. Dash,
S.K. Jindal,
期刊:
Respiration
(Karger Available online 1995)
卷期:
Volume 62,
issue 5
页码: 263-268
ISSN:0025-7931
年代: 1995
DOI:10.1159/000196460
出版商: S. Karger AG
关键词: Cough reflex;Diabetes mellitus;Autonomic neuropathy;Citric acid
数据来源: Karger
摘要:
The cough reflex, a vagus-mediated respiratory protective reflex, was investigated in diabetics and healthy controls by establishing a cough reflex threshold to increasing concentrations of citric acid aerosol. Diabetics with autonomic neuropathy (n = 20), whether overtly symptomatic (n = 5) or evident only on certain non-invasive cardiovascular autonomic function tests, were found to have significantly (p < 0.05 by 0χ2 100%, median value 50%) in contrast to either the non-neuropathic diabetics (n = 20) or normal controls (n = 20; range 1-10%, median value 2%). This difference suggests vagal (parasympathetic) denervation of the respiratory tract, with possible serious consequences, hitherto little appreciated
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