Distribution of Cyclosporin A between Blood Cells and Plasma of Cardiac and Renal Transplant Recipients
作者:
C. Hamberger,
S. Urien,
J. Barre,
M. Brandebourger,
M. Lemaire,
Ph. Lang,
C. Buisson,
D. Loisance,
J. Cachera,
G. Lagrue,
J. Tillement,
期刊:
Therapeutic Drug Monitoring
(OVID Available online 1988)
卷期:
Volume 10,
issue 1
页码: 28-33
ISSN:0163-4356
年代: 1988
出版商: OVID
关键词: Blood cells;Distribution;Cyclosporin A.
数据来源: OVID
摘要:
The relationship between blood cells and plasma concentrations of cyclosporin A (Cy A) determined by radioimmunoassay, was investigated in 12 heart and 12 kidney transplant recipients. The decision between a linear and nonlinear model was made according to a standardized residuals plot. We observed high blood cells-plasma concentration ratios in the two groups, indicating a high affinity of Cy A for blood cells. The distribution of Cy A between blood cells and plasma was ascribed to a nonlinear saturable model in the two groups. According to our results we have simulated the blood-plasma concentration ratio of Cy A as a function of plasma Cy A concentration and he-matocrit.
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