Effect of steroid hormones on liver cells in culture
作者:
M. Vetterlein,
L. Desser‐Wiest,
期刊:
Journal of Toxicology and Environmental Health
(Taylor Available online 1979)
卷期:
Volume 5,
issue 2-3
页码: 561-564
ISSN:0098-4108
年代: 1979
DOI:10.1080/15287397909529767
出版商: Taylor & Francis Group
数据来源: Taylor
摘要:
A variety of liver and hepatoma cell lines were incubated in the presence of corticosterone. DNA synthesis was inhibited in some but not all cell lines. One of them, the Fu 5a clone of the Reuber hepatoma cell line, was subjected to corticosterone for 48 h. Incorporation of labeled thymidine into DNA was inhibited up to 10%. Afterward, corticosterone was removed. DNA synthesis then increased 16‐fold relative to controls. It was concluded that corticosterone blocks these cells in late G1phase of the cell cycle and thus leads to synchronization.
点击下载:
PDF (168KB)
返 回