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Incorporation of125I,134I, and99mTe in some Pharmaceutics and Hormones

 

作者: M. F. Abdel Wahab,   Y. M. Megahed,  

 

期刊: Isotopenpraxis Isotopes in Environmental and Health Studies  （Taylor Available online 1973）
卷期: Volume 9, issue 5  

页码: 166-168

 

ISSN:0021-1915

 

年代: 1973

 

DOI:10.1080/10256017308623197

 

出版商: Taylor & Francis Group

 

关键词: hormons;iodine isotopes;labelling methods;organic compounds;125, 131I;pharmaceuticals;technetium isotopes;99mTe

 

数据来源: Taylor

 

摘要:

In-vitro-labelling of vasopressin and tofranil using radioactive iodine and lechnelium, is carried out by direct interaction between nascent halogen and the macromolecules. Labelling takes place at the favourable pH in the tyrosyl residue of the molecule, yielding a die-iodo derivative or similar. The present method had the advantage of being simple rapid and gives labelled compounds of high specific activity. The gel-filtration method furnished labelled compounds with a minimum degradation products.

 

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