Interaction between paired‐pulse facilitation and long‐term potentiation in the projection from hippocampal area CA1 to the subiculum
作者:
Sean Commins,
John Gigg,
Michael Anderson,
Shane O'Mara,
期刊:
NeuroReport
(OVID Available online 1998)
卷期:
Volume 9,
issue 18
页码: 4109-4113
ISSN:0959-4965
年代: 1998
出版商: OVID
关键词: Hippocampus;Long-term potentiation;Paired-pulse facilitation;Subiculum;Time-dependency
数据来源: OVID
摘要:
STUDIES of the interaction between long-term potentiation (LTP) and paired-pulse facilitation (PPF) may throw light on the role of presynaptic factors in LTP. We examine here, for the first time, the nature of PPF in the CA1-subiculum projection. PPF peaks at a05ms interstimulus interval (ISI) and is evident at ISIs from 10 to 500 ms. There is no PPF effect at a 1000 ms ISI. PPF decreases in magnitude post-LTP induction across the middle range of ISI values tested (30, 50 and 100 ms). There is a positive correlation between initial PPF values and LTP; this correlation increases as the ISI increases. Initial values and the change in PPF post-LTP are also negatively correlated
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