ULTRASTRUCTURAL STUDY OF ERYTHROPHAGOCYTOSIS IN THE RAT BONE MARROW: II. IRON METABOLISM IN RETICULUM CELLS FOLLOWING RED CELL DIGESTION
作者:
PER F. MARTON,
期刊:
Scandinavian Journal of Haematology
(WILEY Available online 1975)
卷期:
Volume 15,
issue S23
页码: 27-48
ISSN:0036-553X
年代: 1975
DOI:10.1111/j.1600-0609.1975.tb01096.x
出版商: Blackwell Publishing Ltd
数据来源: WILEY
摘要:
Intracellular transport and storage of iron in bone marrow reticulum cells can be studied in the electron microscope by the recognition of iron macromolecules. Following artificially increased bone marrow erythrophagocytosis ferritin molecules accumulate both in the cell sap and in the lysosomes of erythroclastic reticulum cells. Persistent iron loading transforms lysosomes into siderosomes, after which haemosiderin may be formed by gradual transformation of ferritin. The bone marrow reticulum cell shows evidence suggestive of autophagy, a process which may allow for the transfer of cell sap ferritin into lysosomes, as documented for other types of iron storing cells.
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