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Repeated Swim Stress and Peripheral-Type Benzodiazepine Receptors

 

作者: Ruth Burgin,   Ronit Weizman,   Moshe Gavish,  

 

期刊: Neuropsychobiology  (Karger Available online 1996)
卷期: Volume 33, issue 1  

页码: 28-31

 

ISSN:0302-282X

 

年代: 1996

 

DOI:10.1159/000119245

 

出版商: S. Karger AG

 

关键词: Swim stress;[3H]PK 11195;Peripheral-type benzodiazepine receptor

 

数据来源: Karger

 

摘要:

The effect of daily forced swimming (15 min) of rats for 21 consecutive days on peripheral-type bentodiazepine receptors (PBR) was investigated. A significant reduction (–17%; p < 0.05) was observed in renal PBR in the stressed animals. A nonsignificant reduction of –18% was detected in adrenal PBR. The maximal binding capacity of [3H]PK 11195 was unaltered in the liver, heart, testis and thymus. It seems that the kidney is especially sensitive to repeated stress. The renal PBR reduction may be related to habituation to stress, and may reflect an adaptatory mechanism aimed at preventing long-term stress-induced overactivity of the reninangiotensin sys

 

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