Argyrophilic Proteins of the Nucleolar Organizer Region in Acute Leukemias and Its Relation to the S-Phase Fraction of Leukemic Cells
作者:
Shinobu Nakamura,
Yasushi Takeda,
Yohko Okabe,
Takashi Yoshida,
Shigeki Ohtake,
Kazumi Kobayashi,
Masatoshi Kanno,
Tamotsu Matsuda,
期刊:
Acta Haematologica
(Karger Available online 1992)
卷期:
Volume 87,
issue 1-2
页码: 6-10
ISSN:0001-5792
年代: 1992
DOI:10.1159/000204705
出版商: S. Karger AG
关键词: Acute leukemia;Ag-NOR;Bromodeoxyuridine;S-phase fraction
数据来源: Karger
摘要:
Nucleolar organizer regions (NORs) are loops of DNA which transcribes to ri-bosomal RNA. The NOR-related protein becomes visible in nucleus by a silver-staining technique under a light microscope, and it has been named argyrophilic protein of NOR (Ag-NOR). In various malignancies, the correlation between the proliferation potential of tumor cells or histological grade and the number of Ag-NORs has been reported. In this study, we investigated the Ag-NOR of acute leukemic cells and its relation to the in vivo proportion of bone marrow leukemic cells in DNA synthetic phase. The number of Ag-NORs in bone marrow leukemic cells was more than that in peripheral blood (means values 2.78 and 2.48, respectively, p < 0.01). This result shows that the number of Ag-NORs reflects the vigorous proliferative potential of bone marrow leukemic cells. However, no significant correlation was obtained between the number of Ag-NORs and the bromodeoxyuridine-labeling indices (r =0.2064). These results suggest that Ag-NOR might be one of the markers for cellular proliferation in leukemia, while DNA synthesis of leukemic cells do not seem to be directly related to Ag-NOR. In order to clarify the role of Ag-NOR in leukemia, further studies are needed.
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