Hodgkin’s disease in HIV-infected individuals
作者:
Michele Spina,
Simonetta Sandri,
Umberto Tirelli,
期刊:
Current Opinion in Oncology
(OVID Available online 1999)
卷期:
Volume 11,
issue 6
页码: 522-522
ISSN:1040-8746
年代: 1999
出版商: OVID
数据来源: OVID
摘要:
The clinical and pathologic characteristics of Hodgkin’s disease as they are diagnosed in patients with HIV infection differ from those of the general population. In fact, a higher frequency of unfavorable histologic subtypes, advanced stage, and poor therapeutic outcome have been reported in the HIV setting. Complete response rate after chemotherapy ranges from approximately 45% to 70%, although the disease-free survival is very short, and the median overall survival is only 18 months. The survival of these patients may be improved by the optimal combination of antineoplastic and antiretroviral treatment with the support of hematologic growth factors. However, new strategies of therapeutic intervention must be explored.
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