Physiological and Pathophysiological Role of the Epithelial Sodium Channel in the Control of Blood Pressure
作者:
Edith Hummler,
Bernard C. Rossier,
期刊:
Kidney and Blood Pressure Research
(Karger Available online 1996)
卷期:
Volume 19,
issue 3-4
页码: 160-165
ISSN:1420-4096
年代: 1996
DOI:10.1159/000174065
出版商: S. Karger AG
关键词: Sodium reabsorption;Hypertension;Hypotension;Transgenic mice;Human disease;Mouse model;Kidney;Pseudoaldosteronism
数据来源: Karger
摘要:
Blood pressure regulation is an integrated physiological phenomenon known to be influenced by many biological processes and by a variety of environmental factors. Epidemiological studies nevertheless suggest that up to 30% of the variation in blood pressure could be due to genetic factors. Thus, mutations in genes that control blood pressure may be the underlying cause of essential hypertension. Arterial blood pressure is critically dependent on the sodium balance and the regulation of renal sodium excretion is one of the most important homeostatic functions of the body. The identification of genes encoding proteins that transport Na+ across cells of the kidney tubules and of those regulating the activity of these sodium-transporting proteins will therefore bring further insights into the pathophysiology of salt-sensitive hypertension.
点击下载:
PDF
(1191KB)
返 回