Bioavailability to rats and toxicological potential in mice of bound residues of malathion in beans
作者:
S.M.A.D. Zayed,
M. Farghaly,
I.Y. Mostafa,
期刊:
Journal of Environmental Science and Health, Part B
(Taylor Available online 1992)
卷期:
Volume 27,
issue 4
页码: 341-346
ISSN:0360-1234
年代: 1992
DOI:10.1080/03601239209372784
出版商: Taylor & Francis Group
关键词: Beans;14C‐malathion;Bound residues;Bioavailability;Toxiclty
数据来源: Taylor
摘要:
Under conditions of local practice, the application of 2,3‐succinate‐14C‐malathion on beans led to the formation of 17–18% of bound14C‐ residues after 30 weeks. When fed to rats, 75% of these residues became bioavailable after 2 days with the major part, excreted via expired air (8%) and urine (60%). The main radioactive metabolites detected in urine were malathion monocarboxylic acid and malathion dicarboxylic acid. Feeding of bound residues to mice (1.8 ppm in feed) for 90 days resulted in a reduction in body weight gain after 60 days and inhibition of erythrocyte cholinesterase activity after 90 days. Increased levels of serum glutamic oxaloacetic transaminase and alkaline phosphatase were also observed. The results strongly suggest that bean‐bound malathion residues can cause adverse biological effects in mice.
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