Neuronal inclusions of Parkinson's disease
作者:
W. R. G. Gibb,
T. Scott,
A. J. Lees,
期刊:
Movement Disorders
(WILEY Available online 1991)
卷期:
Volume 6,
issue 1
页码: 2-11
ISSN:0885-3185
年代: 1991
DOI:10.1002/mds.870060103
出版商: Wiley Subscription Services, Inc., A Wiley Company
关键词: Lewy body;Pale body;Parkinson's disease;Substantia nigra;Locus ceruleus;Filament
数据来源: WILEY
摘要:
AbstractTwo distinct neuronal inclusions occur in Parkinson's disease. The Lewy body is the diagnostic hallmark and is recognized by its eosinophilic body and unstained halo. It can be found in specific regions of the nervous system, where its frequency, size, shape, and structure differ. Large neurons of the dorsal vagal nucleus and sympathetic ganglia often contain particularly large quantities of Lewy‐body‐like matter. It consists of filament in the outer part and electron dense material in the core, the outer part staining with silver and with antibodies to neurofilament and tubulin. The pale body is restricted to the substantia nigra and locus ceruleus. It does not react with conventional stains, silver, or neurofilament antibodies, and has a homogeneous structure with a granular and vesicular surface texture. It contains sparse granular matter, vacuoles, and filaments, surrounded by melanin. The Lewy body and pale body may be juxtaposed or contiguous in some cells, but their distinct appearances and structures indicate that they are separate inclusi
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