The Multixenobiotic Resistance Mechanism in Aquatic Organisms
作者:
KurelecBranko,
期刊:
Critical Reviews in Toxicology
(Taylor Available online 1992)
卷期:
Volume 22,
issue 1
页码: 23-43
ISSN:1040-8444
年代: 1992
DOI:10.3109/10408449209145320
出版商: Taylor&Francis
关键词: multixenobiotic resistance;multidrug resistance;mussel;sponges;fish;mdrl;mRNA;glycoprotein P170;aquatic organisms
数据来源: Taylor
摘要:
AbstractMany aquatic organisms thrive and reproduce in polluted waters. This fact indicates that they are well equipped with a defense system(s) against several toxic xenobiotics simultaneously because water pollution is typically caused by a mixture of a number of pollutants. We have found that the biochemical mechanism underlying such“multixenobiotic”resistance in freshwater and marine mussel, in several marine sponges, and in freshwater fish is similar to the mechanism of multidrug resistance (MDR) found in tumor cells that became refractory to treatment with a variety of chemotherapeutic agents. All these organisms possess a verapamil-sensitive potential to bind 2-acetylaminofluorene and vincristine onto membrane vesicles. They all express mRNA formdr1 gene, andmdr1 protein product, the glycoprotein P170. Finally, inin vivoexperiments, the accumulation of xenobiotics is enhanced in all investigated organisms in the presence of verapamil, the inhibitor of the P170 extrusion pump. The knowledge that the presence of one xenobiotic may block the pumping out, and hence accelerating accumulation, of others, may help us to understand and interprete our present and past data on different environmental parameters obtained using indicator organisms.
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